ammonium monovanadate: a versatile and reusable catalyst for friedel-crafts alkylation and michael addition of indoles

Ammonium monovanadate: a versatile and reusable catalyst for Friedel-Crafts alkylation and Michael addition of indoles

Ammonium monovanadate (NH4VO3) has been devoted as an efficient, commercially available, eco-friendly and reusable catalyst for the synthesis of bis(indolyl)methanes (BIMs), oxindole derivatives and also Michael adducts of indoles at 50 °C under solvent-free conditions. The reusability of this solid acid catalyst in addition with its selectivity has also been examined.

Ammonium monovanadate: a versatile and reusable catalyst for Friedel-Crafts alkylation and Michael addition of indoles

Ammonium monovanadate (NH4VO3) has been devoted as an efficient, commercially available, eco-friendly and reusable catalyst for the synthesis of bis(indolyl)methanes (BIMs), oxindole derivatives and also Michael adducts of indoles at 50 °C under solvent-free conditions. The reusability of this solid acid catalyst in addition with its selectivity has also been examined.

Catalytic asymmetric tandem Friedel–Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans

The enantioselective tandem Friedel-Crafts alkylation/Michael addition reaction of indoles with nitroolefin enoates catalyzed by a diphenylamine-linked bis(oxazoline)-Zn(OTf)2 complex was investigated. This tandem reaction afforded functionalized chiral chromans in good yields with moderate to high stereoselectivities (up to 95:5 dr, up to 99% ee).

Friedel-Crafts alkylation of Phenol using Ionic Liquid as Catalyst

Friedel-Crafts alkylation of indoles with epoxides using PW12-APTES@SBA-15

H3PW12O40 (PW12) was immobilized over mesoporous alumina through the reaction of mesoporous alumina functionalized 3-aminopropyl triethoxy silane (3-APTES) and PW12. The surface properties of the functionalized nanocomposite was analyzed by a series of characterization techniques like elemental analysis, FTIR and XRD. XRD and adsorption–desorption analysis shows that the mesostructure of silica...

Enhanced Efficiency of Thiourea Catalysts by External Brønsted Acids in the Friedel–Crafts Alkylation of Indoles

A novel study of external Brønsted acid-assisted thiourea catalysts in the asymmetric FriedelCrafts alkylation of indoles with nitroalkenes is reported. The final 3-substituted indoles derivatives are synthesized with better results by cooperative effect between chiral thiourea and a Brønsted acid additive (1a·HA), than those obtained with sole thiourea catalyst 1a. The effect of diverse catal...